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KMID : 0914820130130020121
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Journal of the Korean Gastric Cancer Association
2013 Volume.13 No. 2 p.121 ~ p.125
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Advanced Gastric Cancer Associated with Disseminated Intravascular Coagulation Successfully Treated with 5-fluorouracil and Oxaliplatin
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Lee Dong-Seok
Yoo Seung-Jin
Oh Ho-Suk
Kim Eun-Jung
Oh Kwang-Hoon
Lee Sang-Jin
Park Jong-Kyu
Ahn Yong-ChelAhn Yong-Chel
Eom Dae-Woon
Ahn Heui-June
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Abstract
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Gastric cancer patients with acute disseminated intravascular coagulation experiences a rare but severe complication resulting in a dismal prognosis. We report a case of advanced gastric cancer complicated with disseminated intravascular coagulation with intractable tumor bleeding which was successfully treated with chemotherapy consisting of 5-fluorouracil and oxaliplatin. The patient was a 63-year-old man who complained of abdominal pain, melena, and dyspnea on 24 November 2010. We diagnosed stage IV gastric cancer complicated by disseminated intravascular coagulation. Gastric tumor bleeding was not controlled after procedures were repeated three times using gastrofiberscopy. With the patient’s consent, we selected the 5-fluorouracil and oxaliplatin combination chemotherapy for treatment. After one cycle of 5-fluorouracil and oxaliplatin therapy, symptoms of bleeding improved and the disseminated intravascular coagulation process was successfully controlled. The primary tumor and multiple metastatic bone lesions were remarkably shrunken and metabolically remitted after eight cycles of chemotherapy. In spite of progression, systemic chemotherapy is effective in disease control; further, the patient gained the longest survival time among cases of gastric cancer with disseminated intravascular coagulation.
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KEYWORD
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Stomach neoplasms, Disseminated intravascular coagulation, Fluorouracil, Oxaliplatin
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